All systems should be cleaned thoroughly before introduction of the hydrazine, and a nitrogen atmosphere should be maintained over the system at all times. (Ref. The NIOSH Manual of Analytical Methods (NMAM) is a collection of methods for sampling and analysis of contaminants in workplace air, and in the blood and urine of workers who are occupationally exposed. Immediately flush contaminated areas with copious amounts of water. Calibration curve for the colorimetric screening procedure. In Fassett, D.W., and Irish, D.D. UV detector at 313 nm1.5 mL/min of MeOH/H2O: 80/20reverse phase C18 column25-µL direct injection of samples from All open chemicals should be used only in a fume hood. (Ref. The sensitivity will vary somewhat with the particular instrument used in the analysis. 540-73-8 1,2-Dimethylhydrazine. Organic Methods Evaluation BranchOSHA Salt Lake Technical CenterSalt Lake City, UT 84165-0200, Hydrazine in air has been determined by collection in 0.1 M hydrochloric acid and analysis by a colorimetric procedure using p-dimethylaminobenzaldehyde. The coefficient of variation for standards run during this study was 0.018. Air being sampled should not pass through any hose or tubing before entering the Gas Chrom R tube. In humans, the vapor is immediately irritating to the nose and throat and causes dizziness and nausea; itching, burning, and swelling of the eyes develop over a period of several hours. Some examples of workers at risk of being exposed to hydrazine include the following: NIOSH recommends that employers use Hierarchy of Controls to prevent injuries. Figure 4.6.1. If hydrazine is detected, it will be necessary to quantitate it by the analytical HPLC procedure. The Department of Labor does not endorse, takes no responsibility for, and exercises no control over the linked organization or its views, or contents, nor does it vouch for the accuracy or accessibility of the information contained on the destination server. 2218-2219, 2222-2225. Oxidizers, hydrogen peroxide, nitric acid, metallic oxides, acids ; Department of the Air Force, USAF School of Aerospace Medicine (AFSC), "Hydrazine in Air", Brooks Air Force Base, Texas (1979). Occupational Safety and Health Administration The amount of sample that can be taken is limited by the total milligrams the acid coated Gas Chrom R will adsorb before overloading. South Plainfield, NJ 07080 . [Note: A solid below 36°F.] Samples and standards are read against a reagent blank at 465 nm. Refrigerated storage samples. Handle with due care. Hydrazines are highly reactive and easily catch fire. ), The overall detection limit of the colorimetric screening procedure is 0.13 µg of hydrazine per sample (0.005 ppm or 0.0065 mg/m3). Useful search terms for hydrazine include “diamine,” “hydrazine (anhydrous),” and “hydrazine base.”. Personnel Protection (Section 4.4. This includes an additional ±5% for sampling error. Follow the OSHA regulations for respirator use (See title 29, Section 190.134, Code of Federal Regulations). Hydrazine is used in many industries, such as the manufacturing of rocket propellants and fuels for spacecraft. The level of harm depends upon the dose, duration, and work being done. 57-14-7 1 Dimethylhydrazine; CAS No. Tubes were prepared by packing a one-inch section in the middle of a 4-in. H410 Very toxic to aquatic life with long lasting effects. Recurrent exposure to hydrazine hydrate has been reported to cause contact dermatitis of the hands without systemic intoxication. 5.2. Method No. Workers may be harmed from exposure to hydrazine. The level of harm depends upon the dose, duration, and work being done. (ed. The tubes should be placed vertically during sampling. Color reagent - 1.5 g of p-dimethylaminobenzaldehyde (reagent grade) to 100 mL with methyl alcohol (reagent grade). Cook, L.R., Glenn, R.E. This results in a concentration of 0.100 µg/µL. A 25-µL syringe for injections or an autosampler. Screw cap (Teflon-lined) centrifuge tubes (or culture tubes if can be used in a centrifuge) capable of holding a minimum of 10 mL. These stored samples were analyzed over a period of 14 days. A liquid chromatograph equipped with a UV detector. This includes: Diluted aqueous solutions of hydrazine are capable of releasing hydrazine vapors to the surrounding atmosphere. Care must be exercised to prevent explosive conditions either in storage or processing. Recommended air volume and sampling rate: Standard error of estimate at the target concentration: Evaluated method. Transfer contents to a non-leaking container or storage vessel. The washed material was dried overnight at 110°C. A column capable of separating benzalazine from benzaldehyde and any interferences. Pipets and syringes for preparing standards, making dilutions, and dispensing reagents. (Section 4.6.) Do not store near combustible materials. A known amount of the dried Gas Chrom R was weighed into a round bottom flask. Twenty liters of air at approximately 80% relative humidity were pulled through each sample at 0.2 L/min. 2nd ed. If hydrazine odors are detected, control measures should be taken immediately. B. Lippincott Company: Philadelphia, 1978; p. 284-285. (Section 1.1.2.) 5.5. This is equal to 0.16 ng, or 0.0012 ppm (0.0016 mg/m3) for the recommended air volume of 20 L. The chromatogram is shown in Figure 4.1. NIOSH skin notation (SK) profile: Hydrazine—Understanding the hazards related to skin contact with chemicals is a critical component of modern occupational safety and health programs. TTY ), The detection limit of the analytical HPLC procedure is 0.16 ng per injection. : 302-01-2 . 5.5.) Collection on sulfuric acid coated Gas Chrom R, desorption with water and analysis with a colorimetric screening or an HPLC procedure. Transfer the Gas Chrom R sections to separate centrifuge (or culture) tubes. Since the extraction efficiency is essentially 100%, the reliable quantitation limits are the same as the detection limits of the overall procedures for both screening and HPLC procedures. Attach the sampling equipment on the employee so that it does not interfere with worker performance or safety. 200 Constitution Ave NW Dissolve 0.4060 g of hydrazine sulfate in 1 L of 0.1 N sulfuric acid. (Ref. Immediately Dangerous to Life or Health (IDLH) Value Profile: Hydrazine … Sutton, W.L. An amount of sulfuric acid equivalent to 20% of the weight of the Gas Chrom R is diluted with enough methyl alcohol so that when the solution is added to the Gas Chrom R, it will completely cover it. Butyl rubber is the material of choice when handling hydrazine. 2., pp. Benzalazine has a maximum absorption at 300 nm. ), The pooled coefficient of variation obtained from replicate determinations of analytical standards at 0.5, 1.0, and 2.0 times the target concentration is 0.008 by the HPLC procedure. Storage The pumps are usually calibrated for one tube only. 1. The calibration curve is shown in Figure 4.4. ): "Industrial Hygiene and Toxicology", ed. Storage tanks should be properly diked to contain any major spills. Visit NIOSH’s page on Managing Chemical Safety in the Workplace to learn more about controlling chemical workplace exposures. The Department of Labor also cannot authorize the use of copyrighted materials contained in linked Web sites. Figure Box 440, State College, PA 16801) was resieved through 30/60 mesh sieves. Immediate medical … Hydrazine can be stored without adverse effects, either to the container or to the product, when proper materials of construction are used. The NIOSH Pocket Guide to Chemical Hazards (NPG) helps workers, employers, and occupational health professionals recognize and control workplace chemical hazards. Acute The Air Force reported no breakthrough for samples at concentrations between 0.04 and 27.0 mg/m3 collected at flow rates between 0.2 and 1.6 L/min with collection times up to 6.5 h. (Ref. Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website. fire-polished glass tube. Small vials with Teflon-lined caps capable of holding 3 mL. For problems with accessibility in using figures and illustrations, please contact the Salt Lake Technical Center at 801-233-4900.These procedures were designed and tested for internal use by OSHA personnel. Since it does suffer from potential interferences, the colorimetric procedure was adapted for use as a screening test. This method has been subjected to the established evaluation procedures of the Organic Methods Evaluation Branch. The recommended sampling rate is 0.1 to 1 L/min. Search the HHE database for more information on methyl ethyl ketone. For general storage, the approved container for transporting hydrazine can be used. Shake the vials for a few seconds and then allow them to set for 5 min.

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