2013 Dec;51(10):923-9. doi: 10.3109/15563650.2013.850504. Main differences between propylene glycol and ethylene glycol: Between the two ethylene glycol is a better heat transfer fluid than propylene glycol. Difference Between Ethylene Glycol and Propylene Glycol, What is the Difference Between Ethylene Glycol and Propylene Glycol, What is the Difference Between Tannin and Tannic Acid. 2008 Apr 15;228(2):165-78. doi: 10.1016/j.taap.2007.11.024. Propylene Glycol: IUPAC name for Propylene glycol is Propane-1,2-diol. Propylene Glycol: The molar mass of Propylene glycol is about 76.10 g/mol. By continuing you agree to the use of cookies. Metabolism involves oxidation to the mono- and dicarboxylic acids. Landry GM, Dunning CL, Abreo F, Latimer B, Orchard E, McMartin KE. But large amounts can be toxic. The difference between ethylene glycol and diethylene glycol is that an ethylene glycol molecule is an individual molecule whereas diethylene glycol molecule is formed by the combination of two ethylene glycol molecules via an ether bond. Epub 2013 Nov 25. 5. The molar mass of propylene glycol is about 76.1 g/mol.  |  PubChem Compound Database, U.S. National Library of Medicine, Available here. Similarities and differences across these compounds are explained by metabolic pathways. Ethylene Glycol: Ethylene glycol is toxic. HHS National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. However, when considered the uses, both are used for somewhat same purposes. Ethylene Glycol: IUPAC name for Ethylene glycol is Ethane-1,2-diol. Clin Toxicol (Phila). 4. Species differences exist in the metabolism and distribution of toxic metabolites, particularly with the formation of glycolic acids and oxalates (OX) from EG and diethylene glycol (DEG); OX are not formed to a significant degree in higher ethylene glycols. “1,2-Propanediol.” National Center for Biotechnology Information. This means it absorbs water when exposed to the atmosphere. 3. Acute experimental poisoning by diethylene glycol: acid base balance and histological data in male rats. PubChem Compound Database, U.S. National Library of Medicine, Available here. What is Propylene Glycol      – Definition, Applications 3. Ethylene Glycol: The molar mass of Ethylene glycol is about 62.07 g/mol. However, it is a moderately toxic compound. It is generally considered safe. This site needs JavaScript to work properly. COVID-19 is an emerging, rapidly evolving situation. Diethylene glycol induced histologic changes within the kidneys without kidney oxalate deposition. Maximal kidney oxalate levels, following ethylene glycol dosage, occurred concurrently with peak blood oxalate concentrations. 3. Wittschieber D, Heuberger K, Schulz R, Köhler H, Varchmin-Schultheiß K. Forensic Sci Med Pathol. Elimination is primarily through the urine as the parent compound or the monoacid, and, in the case of EG, also as exhaled carbon dioxide. However, it is very useful as a chemical and can be found in many household items such as detergents, cosmetics, etc. 1. Propylene Glycol: Propylene Glycol is a synthetic organic compound that has the chemical formula C 3 H 8 O 2. Blood concentrations of ethylene and diethylene glycol were evaluated in Sprague-Dawley rats at varying intervals following oral dosages of the glycols. NIH Both ethylene glycol and propylene glycol are alcoholic compounds which have two –OH groups per molecule. Ethylene and diethylene glycol in rat blood stored under refrigeration at 4 degrees +/- 10 degrees C for a period of 30 days exhibited minimal concentration losses, contrary to previous reports. Corley RA, Wilson DM, Hard GC, Stebbins KE, Bartels MJ, Soelberg JJ, Dryzga MD, Gingell R, McMartin KE, Snellings WM. The boiling point of this liquid is about 198 °C. Ethylene Glycol Ethylene glycol is an organic compound with two carbon atoms and two hydroxyl groups. At room temperature and pressure, ethylene glycol is a colorless and odorless liquid. 2010 Dec;48(10):967-73. doi: 10.3109/15563650.2010.532803. Clipboard, Search History, and several other advanced features are temporarily unavailable. This indicates that propylene glycol has two –OH groups. J Health Pollut. Difference Between Hydrogenation and Hydrogenolysis, What is the Difference Between Thanksgiving and Black Friday, What is the Difference Between Virgin and Extra Virgin Coconut Oil, What is the Difference Between Prosecco Champagne and Sparkling Wine, What is the Difference Between Arrogance and Confidence, What is the Difference Between Grapeseed Oil and Olive Oil, What is the Difference Between Beeswax and Soy Wax. 2. Maximal kidney oxalate levels, following ethylene glycol dosage, occurred concurrently with peak blood oxalate concentrations. Ethylene glycol and propylene glycol are organic compounds with alcohol functional groups. Ethylene and diethylene glycol induced different modes of death in Sprague-Dawley rats. Copyright © 2020 Elsevier B.V. or its licensors or contributors. 2015 Feb 1;282(3):244-51. doi: 10.1016/j.taap.2014.12.010. Toxicity. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. A toxicological review of the ethylene glycol series: Commonalities and differences in toxicity and modes of action.  |  “PropyleneGlycol-stickAndBall” By Karlhahn – Own work (Public Domain) via Commons Wikimedia. 5. The animals dosed with ethylene glycol demonstrated significantly higher oxalate levels, particularly at 8 hr post-dosing, than similar animals dosed with diethylene glycol. USA.gov. 6. Fatal poisoning with diethylene glycol in an unusual setting. Dosimetry considerations in the enhanced sensitivity of male Wistar rats to chronic ethylene glycol-induced nephrotoxicity. No significant risk of the ethylene glycols is expected under normal use patterns. Toxicol Appl Pharmacol. Ethylene glycol is produced when a reaction takes place between the ethylene oxide and water. Ethylene glycol (EG; CAS RN 107-21-1) and its related oligomers include mono-, di-, tri-, tetra-, and penta-EG. A read-across matrix is presented, which considers the common and distinct toxicological properties of each compound. 2019 Dec;15(4):649-652. doi: 10.1007/s12024-019-00123-4. Ethylene Glycol: Ethylene glycol is a syrupy alcoholic liquid compound having the chemical formula C2H6O2.

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